Product Overview
Reactivity
Rabbit, Mouse, Dog, Guinea pig, Cow, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
Target Information
Alternative Names
CEP55; Cancer/testis antigen 111; Centrosomal protein of 55 kDa; C10orf3; CT111; Centrosomal protein 55kDa; URCC6; Up-regulated in colon cancer 6
Function
Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney.
Tissue Specificity
Expressed in embryonic brain. Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex. Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles. Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Short term: store at 4 °C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20 °C. Protect from light.
