Product Overview
Reactivity
Human, Mouse, Rat
Applications
IHC, IHC-P, WB
Target Information
Alternative Names
Centrosomal protein 164kDa; FLJ54767
Function
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia , a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Tissue Specificity
Expressed in several cell lines.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at -20 °C. Avoid freeze-thaw cycles.
Storage Buffer
PBS with 50% glycerol, pH7.3.
Preservative
0.02% Sodium Azide
