CEP152 Rabbit Polyclonal Antibody (aa841-890)

Cat. No.: CLAB-00230361

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human, Mouse
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
IHC, Peptide-ELISA

Target Information

Target Name
CEP152
UniProt No.
Gene ID
Alternative Names
CEP152; Centrosomal protein of 152 kDa; Centrosomal protein 152kDa; KIAA0912; MCPH9; MCPH4; SCKL5; Asterless
Function
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at -20 °C for up to 1 year.

For Research Use Only. Not For Clinical Use.

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