CEP152 Rabbit Polyclonal Antibody (aa825-875)

Cat. No.: CLAB-00230360

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
IP

Target Information

Target Name
CEP152
UniProt No.
Gene ID
Alternative Names
CEP152; Centrosomal protein of 152 kDa; Centrosomal protein 152kDa; KIAA0912; MCPH9; MCPH4; SCKL5; Asterless
Function
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 2-8 °C for up to one year.

For Research Use Only. Not For Clinical Use.

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