Product Overview
Reactivity
Human, Mouse, Rat
Target Information
Alternative Names
Centrosomal protein 135kDa; Centrosomal protein 4 °Centrosomal protein of 135 kDa; Cep135; CEP4; FLJ13621; KIAA0635centrosome protein cep135
Function
Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at -20 °C. Avoid freeze-thaw cycles.
Storage Buffer
PBS with 50% glycerol, pH7.3.
Preservative
0.02% Sodium Azide
