Product Overview
Reactivity
Human, Monkey, Chimpanzee, Orangutan, Gibbon
Target Information
Alternative Names
CEP135; Centrosomal protein of 135 kDa; CEP4; Centrosomal protein 4; Centrosome protein cep135; Centrosomal protein 135kDa; KIAA0635; MCPH8
Function
Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Short term: store at 4 °C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20 °C. Protect from light.
