CEP131 Rabbit Polyclonal Antibody (aa1-50)

Cat. No.: CLAB-00230322

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
ICC, IF, IP, WB

Target Information

Target Name
CEP131
UniProt No.
Gene ID
Alternative Names
CEP131; 5-azacytidine induced 1; AZI1; AZ1; Centrosomal protein 131 kDa; Centrosomal protein of 131 kDa; Cep131; KIAA1118; ZA1
Function
Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport and/or intramanchette trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 2-8 °C for up to one year.

For Research Use Only. Not For Clinical Use.

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