Product Overview
Target Information
Alternative Names
CCDC100; Centrosomal protein 120kDa; Centrosomal protein of 120 kDa; coiled-coil domain containing 100; coiled-coil domain-containing protein 100; DKFZp686I06246; FLJ36090
Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Storage Buffer
PBS, 2% Sucrose.
Preservative
0.09% Sodium Azide
