Product Overview
Reactivity
Human, Chimpanzee
Target Information
Alternative Names
CEP120; Centrosomal protein of 120 kDa; CCDC100; Centrosomal protein 120kDa
Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Short term: store at 4 °C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20 °C. Protect from light.
