CEP-40783, AXL and C-Met Inhibitor

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Cat. No.

CLIA-0130240

Product Size

1 mg 5 mg Custom Size

Product Overview

Description

A potent and elective Inhibitor of AXL and c-Met.

Purity

> 98%

Form

Solid

Alternative Names

N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; RXDX106

Target

AXL and c-Met

Biological Description

CEP-40783 (RDX-106) is a potent and selective inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.

CAS Number

1437321-24-8

Solubility Overview

> 5 mg/mL in DMSO.

Chemical Properties

Chemical Name

N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide

Molecular Weight (Da)

588.60

Molecular Formula

C₃₁H₂₆F₂N₄O₆

PubChem Identifier

71576419

SMILES

CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C.

For Research Use Only. Not For Clinical Use.

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