Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
Potent JAK2 inhibitor.
Biological Description
CEP-33779 is a potent and orally available inhibitor of JAK2 (IC50 = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor cells.
Solubility Overview
~50 mg/mL in DMSO.
Chemical Properties
Chemical Name
N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Molecular Weight (Da)
462.57
Molecular Formula
C24H26N6O2S
SMILES
CN1CCN(CC1)C2=CC=CC(=C2)NC3=NN4C=CC=C(C4=N3)C5=CC=C(C=C5)S(=O)(=O)C
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store in the dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
