Centrosome-targeting Drug Discovery Service

Hundreds of proteins are localized in centrosome, and they are involved in many biological processes such as cell division and cell migration. Therefore, inhibitors targeting centrosomal proteins have been applied in cancers and other centrosome-related diseases therapy successfully. For assisting our global customers making better progress in the therapeutic development of centrosome-related diseases, CD BioSciences provides centrosome-targeting drug discovery service with our advanced technology and experienced experts. In addition, our process chemistry experts can optimize your process and scale up chemical production according to your requirements for API manufacturing.

Promising Centrosome-related Therapeutic Targets of Cancers

Centrosome is of great importance in many biological processes including cell division, cell migration, cell signaling and many others. The abnormalities of centrosome are frequently observed in cancers and many other diseases, which is considered as the motivation of oncogenic phenotypes. Many proteins required in the management of centrosome abnormalities have been identified, and disruption of these proteins can cause cancer-specific inhibition of cell growth. Examples of promising centrosome-related therapeutic target of cancers are as follows.

PLKs: Polo-like kinases (PLKs) are pivotal regulators of cell proliferation and cell survival. PLKs comprise a family of five serine/threonine protein kinases that have key roles in many processes involved in control of the cell cycle, including entry into mitosis, DNA replication and the stress response to DNA damage.

CDKs: Cyclin-dependent kinases (CDKs) play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.

Overview of the mammalian cell cycle driven by CDKs (Dang, Fabin et al., 2021)

AURK: Aurora kinases (AURK) are key regulators of the mitotic spindle formation. AURK family plays a role not only in the mitotic process but also in cell-cycle regulation such as chromosome segregation failure, causing genetic instability, polyploidy and a significantly increased tumor incidence.

Centrosome is a main character in the regulation of the cell cycle, which makes it an important target for cancer therapy. Many promising inhibitors against centrosomal proteins are being tested in preclinical and clinical models.

Our Services

Due to the great importance of the centrosome in several biological processes related to diseases, CD BioSciences provides a one-stop centrosome-targeting drug discovery service for our global customers. Our drug discovery service is cost-effective and time-saving, with professional scientists and an experienced analysis team. Drug discovery services of CD BioSciences include but not limited as follows.

Target Identification: CD BioSciences offers centrosomal target identification service based on different approaches with high-throughput capabilities.

Hit Discovery: Hit discovery helps identifying the molecules with activity against the target. CD BioSciences offers hit discovery service based on high-throughput approaches.

Hit to Lead: The hit to lead phase is the key step of drug discovery, in which the promising compounds are characterized.

Lead Optimization: The most promising lead compounds must undergo an optimization process to improve effectiveness, diminish toxicity and increase absorption.

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Dang, Fabin et al. "Ubiquitin signaling in cell cycle control and tumorigenesis." Cell death and differentiation vol. 28,2 (2021): 427-438.

Our services are for research use only and not for any clinical use.