Centrosome-targeting Drug Development Service

Inquiry

Centrosome plays important role in many biological processes including cell division and cell migration. Due to the importance of centrosome, the abnormalities of centrosome cause many disorders, such as cancers and ciliopathies. Inhibitors targeting centrosomal proteins have been applied in cancers and other centrosome-related diseases therapy successfully. For assisting our global customers making better progress in the therapeutic development of centrosome-related diseases, CD BioSciences provides centrosome-targeting drug development service with our advanced technology and experienced experts. In addition, our process chemistry experts can optimize your process and scale up chemical production according to your requirements for API manufacturing.

Small molecular structure

Overview of Centrosome-targeting Drugs

Centrosome is of important functions in regulating cell cycle, which makes it an attractive target for cancer treatment. Many compounds are used to against proteins involved in the regulation of different cell cycle points including drugs targeting the microtubule dynamics, Plks, Cdks, and AURK inhibitors. Drugs targeting microtubule dynamics include taxanes (paclitaxel and docetaxel) and vinca alkaloids (vinblastine, vincristine, and vinorelbine), which have been applied successfully for treating varieties of cancers, such as breast cancer, ovarian cancer and lung cancer. And a series of acridinones compounds have been found to be promising therapies against cancer causing G2-M arrest, inhibition of cell migration, and apoptosis.

Small Molecule Inhibitors Targeting Centrosome-associated Proteins

Inhibitors	Target	Inhibitor Function
Taxanes, vinca alkaloids	Microtubule	Induce cell cycle arrest
Griseofulvins, nitrofuramides, GF-15	Kinesin-14	Restrain cell mitosis
CW069	HSET	Induces multipolar mitoses only in cells with supernumerary centrosomes
CFI-400945 centrinone, centrinone B	Plk4	Promotes reduction in Plk4-positive cancer cells and the formation of polyploidy
VX-680, hesperadin, ZM447439, AT-9283, MLN-8054, R-763, SU6668, PHA-739358	Aurora-A	Inhibit tumor growth
CCB02	CPAP-Tubulin Inhibitor	Binding to tubulin and competing for the CPAP binding site of β-tubulin, shows potent anti-tumor activity.

Because chromosomal instability (CIN) and centrosome abnormalities are widespread and specific phenotypes of cancer cells, approaches that target these features have the potential to be effective against a wide range of malignancies. Several compounds have been identified to be the promising therapeutic drug of cacer, which inhibit chromosome missegregation or specifically killing aneuploid cells.

Centrosome-driven pathways to CIN and targeting drugs (Cosenza MR, et al., 2016)

Our Services

With years of experience in drug development and rich knowledge of the centrosome, CD BioSciences provides a one-stop centrosome-targeting drug development service for our global customers. Our drug development service is cost-effective and time-saving, which can help you achieve milestones in centrosome-targeting drug development. Drug development services of CD BioSciences include but not limited as follows.

Preclinical Toxicological Evaluation

Test any substance as a drug on animals at various levels before clinical use in order to ensure complete human safety in each and every aspect.

Preclinical Pharmacological Evaluation

Preclinical pharmacological evaluation helps transform findings from the laboratory and basic science into the clinical practice.

ADME/DMPK

Including drug metabolism and pharmacokinetics (DMPK) service, and analysis of absorption, distribution, metabolism and excretion (ADME).

Stability Testing

Stability testing is for providing evidence of drug stability to ensure safety and effectiveness.

Animal Models

Animal models are powerful tools to make sure the safety of drugs before clinical testing.

Bioanalytical Services

Bioanalytical analysis provides valuable information for early clinical practice.

Preclinical Formulation Development

Preclinical formulation development is for developing the optimal formulation that can precisely match customers' requirements.

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

Cosenza MR, et al. Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues. Chromosome Res. 2016;24(1):105-126.

Our services are for research use only and not for any clinical use.