Centrosome mAb Development Service

Anti-centrosome monoclonal antibodies are powerful tools for centrosome study, as well as therapeutic and diagnostic development of centrosome-related diseases. CD BioSciences provides centrosome monoclonal antibody development service with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related disease.

Overview of Anti-centrosome Antibodies

Centrosome is the main microtubule organizing center (MTOC) of most animal cells, which is of important functions in many biological processes, such as cell cycle and cell migration. Anti-centrosome antibodies are important tools in the study of centrosome dynamics and structure. And they are very useful in elucidating the centrosomal protein function and subcellular localization. The key centrosome antibody targets include:

Antibody reactivity to proteins that are associated with centrosome assembly or microtubule function, such as peri-centriolar material-1, isomorph CRA, stathmin1, HS actin gamma1, SUMO/sentrin peptidase 2, and ubiquitin-conjugating enzyme E2 variant 1, is considered as promising targets of the development of cancer diagnosis and therapy.

• Mutation of genes encoding PCM1 and other PCM proteins causes ciliopathy-related human diseases such as Bardet–Biedl syndrome, Joubert syndrome, Meckel Gruber syndrome, primary microcephaly (MCPH), and oral-facial-digital syndrome.
• DMBT1 located in the PCM is considered a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers.
• Dysregulation of LATS2 gene functions have been found in different cancers.

Centrosome antibodies are very powerful tools for studying the mechanisms of these centrosomal gene in related disease, as well as therapeutical and diagnostic development.

Process of mAb Development & Production

The development and production of monoclonal antibody contains several steps from antigen design to antibody purification and validation.

Design of antigen: In terms of antibody development, an antigen is what the antibody will bind to. Antigens are immunized into host species signaling the start of antibody production within the host's immune system.

Choosing suitable host: Choosing the proper animal host is critical to determining which type of antibody you will receive. Each host has specific benefits and drawbacks.

Antibody development: Host is immunized with antigen, and B cells are generated by immune system to produce antibodies. Once antibody titers are at their highest, the spleen cells are extracted from the host to undergo further development.

Our Services

CD BioSciences is committed to providing scientific research institutions and pharmaceutical companies with one-stop custom antibody services. With years of experience in antibody development and production and advanced technology, our professional scientists are willingly to devote themselves for assisting you making better progress in your research. Our centrosome antibody development services include but not limited as follows.

By Host

By Technology

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Our services are for research use only and not for any clinical use.