Product Overview
Target Information
Alternative Names
BM032; CENP-J; centromere protein J; Centrosomal P4.1-associated protein; CPAPMCPH6; LAG-3-associated protein; LAPSCKL4; LIP1microcephaly, primary autosomal recessive 6; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; MGC131581; MGC131582; MGC142222; MGC142224; Sas-4; SASS4
Function
Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles.
Storage Buffer
PBS (pH 7.4).
