CDK5RAP2 Rabbit Polyclonal Antibody

Cat. No.: CLAB-00230250

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
FITC
Applications
ELISA

Target Information

Target Name
CDK5RAP2
UniProt No.
Gene ID
Alternative Names
CDK5RAP2; Cep215; Centrosomal protein 215 kDa; MCPH3; C48; KIAA1633
Function
Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex onto centrosomes. In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis.
Tissue Specificity
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze.

For Research Use Only. Not For Clinical Use.

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