CDC14B Rabbit Polyclonal Antibody

Cat. No.: CLAB-00230205

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Mouse
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
IHC-P

Target Information

Target Name
CDC14B
UniProt No.
Gene ID
Alternative Names
CC14B_HUMAN; Cdc 14B; Cdc 14B1; Cdc 14B2; CDC 14B3; CDC14 cell division cycle 14 homolog B; CDC14 homolog B; Cdc14b; Cdc14B1; Cdc14B2; CDC14B3; Cell division cycle 14 homolog B; Dual specificity protein phosphatase CDC14B; hCDC 14B; hCDC14B; OTTHUMP00000063774
Function
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C long term. Avoid freeze / thaw cycle.
Storage Buffer
0.01% BSA, 50% Glycerol (glycerin, glycerine). pH: 7.2.
Preservative
0.09% Sodium Azide

For Research Use Only. Not For Clinical Use.

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