Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, cell-permeable RARγ-selective agonist.
Biological Description
Potent, cell-permeable RARγ-selective agonist (EC50 values are 140, 28 and 7 nM for RAR-α, β and γ respectively). Shows RARγ-dependent and -independent effects on differentiation and apoptosis. Shows antitumor effects in vivo.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM.
Chemical Properties
Chemical Name
6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Molecular Weight (Da)
398.50
Molecular Formula
C27H26O3
SMILES
O=C(O)c1ccc2cc(ccc2c1)c6cc(C5C3CC4CC5CC(C3)C4)c(O)cc6
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
