Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
A potent, selective, small-molecule modulator of CDK8 and CDK19.
Alternative Names
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Biological Description
CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC50, CDK8 = 2.3 nM; CDK19 = 2.6 nM).
Solubility Overview
> 25 mg/mL in DMSO.
Chemical Properties
Chemical Name
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Molecular Weight (Da)
410.90
Molecular Formula
C21H23ClN6O
SMILES
CN1C2=C(C=C(C=C2)C3=CN=C(C(=C3N4CCC5(CCNC5=O)CC4)Cl)N)C=N1
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store in the dark.
