CCT-241736, FLT3-Aurora Inhibitor

Inquiry

Cat. No.

CLIA-0130239

Product Size

5 mg 25 mg Custom Size

Product Overview

Description

Potent dual FLT3-Aurora inhibitor.

Purity

> 98%

Form

Solid

Target

FLT3-Aurora

Biological Description

CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I.

CAS Number

1402709-93-6

Solubility Overview

Soluble in DMSO to > 100 mM.

Chemical Properties

Chemical Name

6-chloro-7-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine

Molecular Weight (Da)

456.38

Molecular Formula

C₂₂H₂₃Cl₂N₇

PubChem Identifier

71454279

SMILES

CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C.

For Research Use Only. Not For Clinical Use.