Product Overview
Target Information
Alternative Names
CCP110; CP110; Centrosomal protein of 110 kDa; KIAA0419; Centrosomal protein CP110; Cep110
Function
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Tissue Specificity
Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Avoid repeated freeze/thaw cycles. Store at 4 °C for frequent use. Aliquot and store at -20 °C for 12 months.
