Product Overview
Reactivity
Human (predicted: Mouse)
Target Information
Alternative Names
AKT iphosphorylation enhancer; Akt phosphorylation enhancer; APE; Ccdc88a; Coiled coil domain containing 88A; Coiled coil domain containing protein 88A; Coiled-coil domain-containing protein 88A; FLJ10392; G alpha interacting vesicle associated protein; G alpha-interacting vesicle-associated protein; Galpha interacting vesicle associated protein; Girders of actin filament; Girdin; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212
Tissue Specificity
Expressed ubiquitously.
Function
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase -dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at -20 °C. Stable for 12 months at -20 °C.
Storage Buffer
50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride. pH: 7.40.
Preservative
0.02% Sodium Azide
