Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent dual CDC7 and CDK9 kinase inhibitor.
Alternative Names
PHA-767491
Target
CDC7 and CDK9 kinase
Biological Description
Potent Cdc7 and Cdk9 kinase inhibitor (IC50 values are 10 and 34 nM for Cdc7 in the presence of 1.5 µM ATP and Cdk9 respectively). Induces apoptosis in cancer cell lines.
Solubility Overview
Soluble in DMSO to 10 mM.
Chemical Properties
Chemical Name
2-Pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
Molecular Weight (Da)
213.24
Molecular Formula
C12H11N3O
SMILES
C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
