Product Overview
Reactivity
Human (predicted: Mouse, Rat, Cow, Xenopus laevis, Zebrafish, Orangutan, Xenopus tropicalis)
Applications
ICC/IF, IHC-P, IP, WB
Target Information
Alternative Names
Casein Kinase 1 delta; Casein kinase I delta isoform; Casein kinase I isoform delta; CKI delta; CKI-delta; CKId; CKIdelta; CSNK 1D; CSNK1D; HCKID; KC1D_HUMAN; Protein kinase CK1 delta
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
Tissue Specificity
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C long term. Avoid freeze / thaw cycle.
Storage Buffer
50% Glycerol (glycerin, glycerine), PBS, 0.03% Proclin 300. pH: 7.40.
