Product Size
25 mg
5 mg
Custom Size
Product Overview
Description
SIRT1/2 inhibitor.
Biological Description
SIRT1/2 inhibitor (IC50 values are 56 and 59 μM at SIRT1 and SIRT2 respectively). Class III HDAC inhibitor, with no inhibition of class I and II. Promotes G2 cell cycle arrest. Antitumour activity in vitro and in vivo.
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone
Molecular Weight (Da)
360.43
Molecular Formula
C21H16N2O2S
SMILES
S=C4NC(c1ccccc1)=C(Cc2c3ccccc3ccc2O)C(=O)N4
Storage & Handling
Storage Instructions
Store at 4 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
