Calyculin A, Protein Phosphatase Inhibitor

Inquiry

Cat. No.

CLIA-0130139

Product Size

10 μg 50 μg Custom Size

Product Overview

Description

Potent, selective and cell-permeable protein phosphatase inhibitor.

Purity

> 98%

Form

Solid

Target

Protein phosphatase

Biological Description

Potent, selective and cell-permeable protein phosphatase inhibitor (IC50 values are 2 and 1 nM for PP1 and PP2A, respectively). Highly selective over PP2B and PP2C. Active in vivo and in vitro.

Source

Discodermia calyx

CAS Number

101932-71-2

Solubility Overview

Soluble in ethanol and in DMSO.

Chemical Properties

Chemical Name

[(2R,3R,5R,7R,8S,9S)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraenyl]-9-[(E)-3-[2-[(2S)-4-[[(2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate

Molecular Weight (Da)

1009.18

Molecular Formula

C₅₀H₈₁N₄O₁₅P

PubChem Identifier

5311365

SMILES

CC1C(CC2(C(C(C(O2)C(CC(C(C)C(C(C)C=C(C)C(=CC=CC(=CC#N)C)C)O)O)OC)OP(=O)(O)O)(C)C)OC1CC=CC3=COC(=N3)C(C)CCNC(=O)C(C(C(COC)N(C)C)O)O)O

Storage & Handling

Storage Instructions

Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.

For Research Use Only. Not For Clinical Use.