Call Us: 1-631-637-0420
Search

C57BL/6J-Alms1tvrm102/PjnMmjax

Inquiry Now
Cat. No.
CLMM-00270003
Product Type
Age
Sex
Quantity
Common Name
tvrm102
Mutation Type
Chemically Induced Mutation
Strain Type
Coisogenic
Product Overview
These ENU-induced tvrm102 mice carry a mutation in the exon 6 splice donor site of the Alms1 gene and provide a model for Alstrom syndrome with progressive weight gain and slow photoreceptor degeneration.

Genetics

Gene Symbol
Alms1
Gene Name
ALMS1, centrosome and basal body associated
Phenotype
obese; retina photoreceptor degeneration
Strain of Origin
C57BL/6J
Chromosome
6
Molecular Note
This ENU-induced T>C point transition (c. 1080+2 T>C) in the exon 6 splice donor site that unmasks a cryptic splice site 120 bases downstream.

Husbandry

Suggested Controls
C57BL/6J
Breeding Considerations
When maintaining a live colony, heterozygous mice may be bred to each other. The donating investigator indicates that homozygous mice do not breed.
Breeding Strategy
+/+ sibling x Heterozygote
Heterozygote x +/+ sibling
Heterozygote x C57BL/6J (000664)
C57BL/6J (000664) x Heterozygote

For Research Use Only. Not For Clinical Use.

Related Products

Products

Online Inquiry

We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy

Accept Cookies
x