C57BL/6J-Alms1^tvrm102/PjnMmjax

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Cat. No.

CLMM-00270003

Product Type

Age

Sex

Quantity

Common Name

tvrm102

Mutation Type

Chemically Induced Mutation

Strain Type

Coisogenic

Product Overview

These ENU-induced tvrm102 mice carry a mutation in the exon 6 splice donor site of the Alms1 gene and provide a model for Alstrom syndrome with progressive weight gain and slow photoreceptor degeneration.

Genetics

Gene Symbol

Alms1

Gene Name

ALMS1, centrosome and basal body associated

Phenotype

obese; retina photoreceptor degeneration

Strain of Origin

C57BL/6J

Chromosome

Molecular Note

This ENU-induced T>C point transition (c. 1080+2 T>C) in the exon 6 splice donor site that unmasks a cryptic splice site 120 bases downstream.

Husbandry

Suggested Controls

C57BL/6J

Breeding Considerations

When maintaining a live colony, heterozygous mice may be bred to each other. The donating investigator indicates that homozygous mice do not breed.

Breeding Strategy

+/+ sibling x Heterozygote
Heterozygote x +/+ sibling
Heterozygote x C57BL/6J (000664)
C57BL/6J (000664) x Heterozygote

For Research Use Only. Not For Clinical Use.