C57BL/6J-Alms1tvrm102/PjnMmjax

Cat. No.
CLMM-00270003
Product Type
Age
Sex
Quantity
Common Name
tvrm102
Mutation Type
Chemically Induced Mutation
Strain Type
Coisogenic
Product Overview
These ENU-induced tvrm102 mice carry a mutation in the exon 6 splice donor site of the Alms1 gene and provide a model for Alstrom syndrome with progressive weight gain and slow photoreceptor degeneration.

Genetics

Gene Symbol
Alms1
Gene Name
ALMS1, centrosome and basal body associated
Phenotype
obese; retina photoreceptor degeneration
Strain of Origin
C57BL/6J
Chromosome
6
Molecular Note
This ENU-induced T>C point transition (c. 1080+2 T>C) in the exon 6 splice donor site that unmasks a cryptic splice site 120 bases downstream.

Husbandry

Suggested Controls
C57BL/6J
Breeding Considerations
When maintaining a live colony, heterozygous mice may be bred to each other. The donating investigator indicates that homozygous mice do not breed.
Breeding Strategy
+/+ sibling x Heterozygote
Heterozygote x +/+ sibling
Heterozygote x C57BL/6J (000664)
C57BL/6J (000664) x Heterozygote

For Research Use Only. Not For Clinical Use.

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