C10orf90 Rabbit Polyclonal Antibody (aa491-540)

Cat. No.: CLAB-00230158

Product Size: 20 µL 100 µL Custom Size

Product Overview

Reactivity
Human
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
HRP
Applications
WB

Target Information

Target Name
C10orf90
UniProt No.
Gene ID
Alternative Names
C10orf90; Centrosomal protein C10orf90; FATS; RP11-422P15.2; BA422P15.2
Function
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase activity and assemble ubiquitin polymers through 'Lys-11'- , 'Lys-29'- and 'Lys-63'- -linkages, independently of the ubiquitin-conjugating enzyme. Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. May have a role in the assembly of primary cilia.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Short term: store at 4 °C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20 °C. Protect from light.

For Research Use Only. Not For Clinical Use.

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