Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor.
Target
Protein tyrosine phosphatase (PTP)
Biological Description
Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor (IC50 values are 0.9 (PTP1B), 1.7 (TCPTP), 0.09 (SHP-2), 1.5 (LAR) and 0.7 (YopH) μM). Active in vivo and cell-permeable.
Solubility Overview
Soluble in DMSO to 50 mM and in ethanol to 20 mM.
Chemical Properties
Chemical Name
4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Molecular Weight (Da)
241.25
Molecular Formula
C14H11NO3
SMILES
OC=2C(=O)c1ccccc1C3=NC(=O)C(C)(C)C=23
Storage & Handling
Storage Instructions
Store at -20 °C. It is important to note that this product is reported to be light sensitive. Store in the dark. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
