BN-82002, CDC25 Phosphatase Inhibitor

Inquiry

Cat. No.

CLIA-0130142

Product Size

5 mg 25 mg Custom Size

Product Overview

Description

Potent, selective CDC25 Phosphatase Inhibitor I.

Purity

> 98%

Form

Solid

Target

CDC25

Biological Description

BN-82002 is a cell-permeable CDC25 Phosphatase Inhibitor. BN-82002 is a potent, cell-permeable, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN-82002 inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro. It impairs the proliferation of tumoral cell lines and increases cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation.

CAS Number

396073-89-5

Solubility Overview

Soluble in DMSO to > 100 mM.

Chemical Properties

Chemical Name

4-(dimethylamino)-2-methoxy-6-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]phenol

Molecular Weight (Da)

359.43

Molecular Formula

C₁₉H₂₅N₃O₄

PubChem Identifier

9798923

SMILES

CN(C)C1=CC(=C(C(=C1)OC)O)CN(C)CCC2=CC=C(C=C2)[N+](=O)[O-]

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C.

For Research Use Only. Not For Clinical Use.