BMS 345541, IKK-2 and IKK-1 Inhibitor

Inquiry

Cat. No.

CLIA-0130119

Product Size

5 mg 50 mg Custom Size

Product Overview

Description

Highly selective cell permeable IKK-2 and IKK-1 inhibitor.

Purity

> 98%

Form

Solid

Target

IKK-2 and IKK-1

Biological Description

Highly selective cell permeable IKK-2 and IKK-1 inhibitor (IC50 values are 0.3 and 4 μM for IKK-2 and IKK-1 respectively). Blocks NF-κB-dependent transcription. Shows anti-inflammatory and radiosensitizing effects in vivo. Orally active.

Source

Synthetic

CAS Number

445430-58-0

Solubility Overview

Soluble in DMSO to 25 mM.

Chemical Properties

Chemical Name

N'-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine

Molecular Weight (Da)

255.32

Molecular Formula

C₁₄H₁₇N₅

PubChem Identifier

9813758

SMILES

CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN

Storage & Handling

Storage Instructions

Store at 4 °C (desiccating conditions).

For Research Use Only. Not For Clinical Use.