Product Overview
Reactivity
Human, Mouse, Rat
Target Information
Alternative Names
biogenesis of lysosomal organelles complex-1, subunit 2; BLOC-1 subunit 2; CEAP; Centrosomal 10 kDa protein; centrosome protein oncogene; Centrosome-associated protein; subunit 2
Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles , such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
Tissue Specificity
Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Storage Buffer
PBS (pH 7.2) and 40% Glycerol.
Preservative
0.02% Sodium Azide
