(±)-Blebbistatin, Inhibitor Of Myosin II

Cat. No.
CLIA-0130303
Product Size
5 mg 25 mg Custom Size

Product Overview

Description
Potent, selective, inhibitor of myosin II.
Purity
> 95%
Form
Solid
Target
Myosin II
Biological Description
Cell-permeable, reversible inhibitor of non-muscle myosin II. Shows high affinity and selectivity for vertebrate and invertebrate Myosin II (IC50 values 0.5-5 μM). Inhibits actin-activated MgATPase activity and in vitro motility of class II myosins. Also inhibits contraction of the cytokinetic ring. Blocks cell blebbing and disrupts directed cell migration and cytokinesis.
Source
Synthetic
CAS Number
674289-55-5
Solubility Overview
Soluble in DMSO to 100 mM.

Chemical Properties

Chemical Name
(±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Molecular Weight (Da)
292.34
Molecular Formula
C18H16N2O2
PubChem Identifier
SMILES
Cc2ccc3N=C1N(CCC1(O)C(=O)c3c2)c4ccccc4

Storage & Handling

Storage Instructions
Store at 4 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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