Beta Catenin Rabbit Polyclonal Antibody

Cat. No.: CLAB-00230105

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human (predicted: Mouse, Rat, Chicken, Xenopus laevis)
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
IHC-P, IP, WB

Target Information

Target Name
CTNNB1
UniProt No.
Gene ID
Alternative Names
b-catenin; Beta catenin; Beta-catenin; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CHBCAT; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289
Function
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Tissue Specificity
Expressed in several hair follicle cell typesbasal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C. Avoid freeze / thaw cycle.
Storage Buffer
PBS, 1% BSA. pH: 7.60.
Preservative
0.1% Sodium Azide

For Research Use Only. Not For Clinical Use.

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