B6;SJL-Plk4^em1Ahol/J

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Cat. No.

CLMM-00270014

Product Type

Age

Sex

Quantity

Common Name

Plk4^Δu

Mutation Type

Endonuclease-Mediated Mutation

Product Overview

Plk4^Δu mice carry a CRISPR/Cas9-made mutation that knocks out start codons of the Plk4 upstream open reading frames uORF1 and uORF2. These mice may be useful for studying the role of Plk4 in centriole biology, regulation of gametogenesis and centrosome amplification in multiple cancers.

Genetics

Allele Symbol

Plk4^em1Ahol

Gene Symbol

Plk4

Gene Name

polo like kinase 4

Strain of Origin

(C57BL/6 x SJL)F2

Husbandry

Suggested Controls

Wild-type from the colony

Breeding Considerations

When maintaining a live colony, heterozygous mice may be bred together. Note that homozygous mice are viable but display dramatically reduced fertility because of a significant depletion of primordial germ cells (PGCs).

Breeding Strategy

Wild-type x Heterozygote
Heterozygote x Wild-type

For Research Use Only. Not For Clinical Use.