B6.129-Aurka^tm1.1Tvd/J

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Cat. No.

CLMM-00270013

Product Type

Age

Sex

Quantity

Common Name

AurA^f

Mutation Type

Targeted Mutation

Strain Type

Congenic

Generation

+pN1

Product Overview

These floxed mice possess loxP sites flanking exon 2 of the Aurka gene and have applications in studies related to regulation of mitosis and carcinogenesis.

Genetics

Allele Symbol

Aurka^tm1.1Tvd

Gene Symbol

Aurka

Gene Name

aurora kinase A

Strain of Origin

129P2/OlaHsd

Chromosome

Molecular Note

An frt and loxP flanked neo cassette was inserted into intron 1 and a third loxP site was inserted into intron 2 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 2 floxed.

Husbandry

Suggested Controls

C57BL/6J

Breeding Considerations

When maintaining a live colony, these mice can be bred as homozygotes.

Coat Color

Black

For Research Use Only. Not For Clinical Use.