AZD-5069, CXCR2 Chemokine Receptor Antagonist

Inquiry

Cat. No.

CLIA-0130145

Product Size

25 mg 5 mg Custom Size

Product Overview

Description

Potent and reversible CXCR2 chemokine receptor antagonist.

Purity

> 98%

Form

Solid

Target

CXCR2 chemokine receptor

Biological Description

A potent and reversible CXCR2 chemokine receptor antagonist with potential anti-inflammatory and antineoplastic activities. Upon administration, CXC chemokine receptor 2 antagonist AZD5069 directly binds to CXCR2 and inhibits its activation. This inhibits CXCR2-mediated signaling and may inhibit tumor cell proliferation in CXCR2-overexpressing tumor cells.

Source

Synthetic

CAS Number

878385-84-3

Solubility Overview

Soluble in DMSO.

Chemical Properties

Chemical Name

N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[(2R,3S)-3,4-dihydroxybutan-2-yl]oxypyrimidin-4-yl]azetidine-1-sulfonamide

Molecular Weight (Da)

476.51

Molecular Formula

C₁₈H₂₂F₂N₄O₅S₂

PubChem Identifier

56645576

SMILES

CC(C(CO)O)OC1=NC(=NC(=C1)NS(=O)(=O)N2CCC2)SCC3=C(C(=CC=C3)F)F

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

For Research Use Only. Not For Clinical Use.