Aurora B Rabbit Polyclonal Antibody

Cat. No.: CLAB-00230060

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human (predicted: Chimpanzee, Rhesus monkey, Gorilla, Orangutan)
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
ICC, IP, WB

Target Information

Target Name
AURKB
UniProt No.
Gene ID
Alternative Names
AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB; AURKB; AURKB_HUMAN; Aurora 1; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora related kinase 2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora-B; Aurora-related kinase 2; Aurora/IPL1 related kinase 2; Aurora/IPL1-related kinase 2; IPL1; PPP1R48; Protein phosphatase 1 regulatory subunit 48; Serine/theronine kinase 12; Serine/threonine protein kinase 12; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK-1; STK1; STK12; STK5
Function
May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex , a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.
Tissue Specificity
High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot and store at -20 °C. Avoid freeze / thaw cycles.
Storage Buffer
1.815% Tris, 1.764% Sodium citrate, 0.021% PBS. pH: 7.
Preservative
0.09% Sodium Azide

For Research Use Only. Not For Clinical Use.

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