Product Overview
Reactivity
Human (predicted: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Xenopus tropicalis, Platypus)
Target Information
Alternative Names
Adenomatous Polyposis Coli; Adenomatous polyposis coli protein; Apc; APC_HUMAN; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; Protein APC
Function
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor -induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Tissue Specificity
Expressed in a variety of tissues.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot and store at -20 °C. Avoid freeze / thaw cycles.
Storage Buffer
1.815% Tris, 1.764% Sodium citrate, 0.021% PBS. pH: 7.
Preservative
0.09% Sodium Azide
