Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, cell-permeable cyclin-dependent kinase inhibitor.
Target
Cyclin-dependent kinase (CDK)
Biological Description
Potent, cell-permeable cyclin-dependent kinase inhibitor (IC50 values are 33 (cdk1/cyclin B), 33 (cdk2/cyclin A), 28 (cdk2/cyclin E) and 20 nM (cdk5/p35)). Inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM). Induces cell cycle arrest at G2/M phase (IC50 = 1.25 μM). Shows apoptotic effects.
Solubility Overview
Soluble in ethanol to 50 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Molecular Weight (Da)
403.91
Molecular Formula
C19H26ClN7O
SMILES
CC(C)C(CO)Nc2nc(Nc1cc(N)cc(Cl)c1)c3ncn(c3n2)C(C)C
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
