Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor.
Target
Cyclin-dependent kinase (CDK) and GSK-3beta
Biological Description
Potent CDK inhibitor (IC50 values are 3.5 (CDK1/cyclin B), 20 (CDK2/cyclin A) and 40 nM (CDK5/p35)). Also displays potent and selective inhibition of GSK-3β (IC50 values are 40 and 4 nM respectively). Antiproliferative effects seen in vitro. Cell-permeable.
Chemical Properties
Chemical Name
7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one
Molecular Weight (Da)
293.28
Molecular Formula
C16H11N3O3
SMILES
[O-][N+](=O)c4cc3c(NC1C3CC(=O)Nc2ccccc12)cc4
Storage & Handling
Storage Instructions
Store at 4 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
