Product Overview
Reactivity
Human (predicted: Mouse)
Applications
ICC/IF, IHC-P, WB
Target Information
Alternative Names
AGBL4; ATP/GTP binding protein like 4; ATP/GTP-binding protein-like 4; CBPC6_HUMAN; CCP6; Cytosolic carboxypeptidase 6; FLJ14442
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot. Store at -20 °C or -80 °C. Avoid freeze / thaw cycle.
Storage Buffer
1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine). pH: 7.00.
Preservative
0.01% Thimerosal (merthiolate)
