Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent EGFR-tyrosine kinase inhibitor.
Alternative Names
Tyrphostin B46
Target
EGFR tyrosine kinase
Biological Description
Potent EGFR-tyrosine kinase inhibitor (IC50 = 700 nM). Blocks Cdk2 activation. Active form of tyrphostin A1. Induces cell arrest at late G1 phase (IC50 values are 6.4 and 9.4 μM for HPV16-immortalized and normal keratinocytes respectively). Shows similar effects to AG 556.
Solubility Overview
Soluble in ethanol and in DMSO to 30 mM.
Chemical Properties
Chemical Name
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide
Molecular Weight (Da)
322.36
Molecular Formula
C19H18N2O3
SMILES
C1=CC=C(C=C1)CCCNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
