Product Size
10 mg
50 mg
Custom Size
Product Overview
Description
Potent, selective EGF receptor tyrosine kinase.
Target
EGF receptor tyrosine kinase
Biological Description
Potent, selective EGF receptor tyrosine kinase inhibitor (IC50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC50 values are 42, 6 and 100 μM respectively). Blocks CDK2 activation leading to cell cycle arrest at late G1 and during S phase.
Solubility Overview
Soluble in DMSO to 75 mM and in ethanol to 75 mM.
Chemical Properties
Chemical Name
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
Molecular Weight (Da)
280.30
Molecular Formula
C16H12N2O3
SMILES
C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
