Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
JAK2/3 inhibitor.
Biological Description
JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM.
Chemical Properties
Chemical Name
(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Molecular Weight (Da)
294.31
Molecular Formula
C17H14N2O3
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
