Product Size
10 mg
50 mg
Custom Size
Product Overview
Description
Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor.
Target
Her2/ErbB 2 and EGFR kinase
Biological Description
Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.
Solubility Overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
(S,E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Molecular Weight (Da)
485.94
Molecular Formula
C24H25ClFN5O3
SMILES
CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
