Product Size
250 mg
1 g
Custom Size
Product Overview
Description
Potent DNMT1 inhibitor. Induces DNA hypomethylation.
Alternative Names
5-AzadCyD; Dacogen; NSC 102816
Biological Description
Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows anti-metabolic and anti-cancer activities in vitro. Active in vivo. At high doses the compound can have effects on other DNA methyltransferases.
Solubility Overview
Soluble in water to 50 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Molecular Weight (Da)
244.21
Molecular Formula
C8H12N4O5
SMILES
C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Unstable; make up solutions fresh and use immediately.
